Analysis of risk factors of lymph node metastasis in rectal neuroendocrine neoplasms using multicenter data

Future Oncol. 2018 Aug;14(18):1817-1823. doi: 10.2217/fon-2018-0059. Epub 2018 Jul 18.

Abstract

Aim: This study was conducted to analyze the risk factors associated with lymph node metastasis in rectal neuroendocrine neoplasms (NENs).

Materials & methods: A total of 419 patients with rectal NENs were enrolled. A univariate analysis of risk factors of lymph node metastasis was conducted using a χ2 test, and a multivariate analysis was conducted using a logistic regression analysis.

Results: Univariate and multivariate regression analysis revealed that tumor size, G grade and the depth of tumor invasion were independent risk factors for lymph node metastasis (p < 0.05).

Conclusion: Rectal NENs patients with a larger tumor size, deeper tumor invasion or a higher G grade had a higher risk of regional lymph node metastasis.

Keywords: neuroendocrine neoplasms; pathology; rectal neoplasms; risk factor; lymph node metastasis.

Publication types

  • Multicenter Study

MeSH terms

  • China / epidemiology
  • Female
  • Humans
  • Lymph Node Excision / standards*
  • Lymph Node Excision / statistics & numerical data
  • Lymph Nodes / pathology*
  • Lymph Nodes / surgery
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neuroendocrine Tumors / epidemiology
  • Neuroendocrine Tumors / pathology*
  • Neuroendocrine Tumors / surgery
  • Practice Guidelines as Topic
  • Rectal Neoplasms / epidemiology
  • Rectal Neoplasms / pathology*
  • Rectal Neoplasms / surgery
  • Retrospective Studies
  • Risk Factors