Biology-Oriented Drug Synthesis (BIODS) Approach towards Synthesis of Ciprofloxacin-Dithiocarbamate Hybrids and Their Antibacterial Potential both in Vitro and in Silico

Chem Biodivers. 2018 Oct;15(10):e1800273. doi: 10.1002/cbdv.201800273. Epub 2018 Sep 24.

Abstract

A novel series of ciprofloxacin-dithiocarbamate hybrids 7a - 7l were designed, synthesized, and evaluated against Gram-positive and Gram-negative bacteria. A significant part of the title compounds showed considerable antibacterial activity against Gram-positive species. The most potent compound against Gram-positive bacteria was 2-chloro derivative 7h and the most potent derivative against Gram-negative bacteria was 3-chloro compound 7i. In vitro antibacterial evaluation of compound 7h against clinically isolated bacteria methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) showed that this compound acted better than ciprofloxacin against the latter bacteria. Docking study of compound 7h in the active site of S. aureus DNA gyrase revealed that this ciprofloxacin-dithiocarbamate derivative interacted with the main components of the active site of the enzyme.

Keywords: BIODS; antibacterial activity; ciprofloxacin; dithiocarbamate; docking study.

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / metabolism
  • Catalytic Domain / drug effects
  • Ciprofloxacin / analogs & derivatives*
  • Ciprofloxacin / chemical synthesis
  • Ciprofloxacin / pharmacology
  • DNA Gyrase / chemistry
  • DNA Gyrase / metabolism
  • Humans
  • Methicillin-Resistant Staphylococcus aureus / chemistry
  • Methicillin-Resistant Staphylococcus aureus / drug effects
  • Methicillin-Resistant Staphylococcus aureus / metabolism
  • Molecular Docking Simulation
  • Staphylococcal Infections / drug therapy*
  • Staphylococcus aureus / chemistry
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / metabolism
  • Thiocarbamates / chemical synthesis*
  • Thiocarbamates / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Thiocarbamates
  • ciprofloxacin dithiocarbamate
  • Ciprofloxacin
  • DNA Gyrase