CRISPR: Stressed about p53?

Miguel Foronda; Lukas E Dow

doi:10.1016/j.molmed.2018.06.010

CRISPR: Stressed about p53?

Trends Mol Med. 2018 Sep;24(9):731-733. doi: 10.1016/j.molmed.2018.06.010. Epub 2018 Jul 17.

Authors

Miguel Foronda¹, Lukas E Dow²

Affiliations

¹ Sandra and Edward Meyer Cancer Center, Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY 10021, USA.
² Sandra and Edward Meyer Cancer Center, Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY 10021, USA; Department of Biochemistry, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address: lud2005@med.cornell.edu.

PMID: 30017531
DOI: 10.1016/j.molmed.2018.06.010

Abstract

Two recent reports show that, in some contexts, CRISPR-mediated genome editing can lead to a p53-mediated stress response and cell-cycle arrest. These findings may help to explain why CRISPR-mediated genetic manipulation in different cell types leads to dissimilar outcomes, and highlights the need for a better understanding of the factors that influence effective genome editing in vitro and in vivo.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

CRISPR-Cas Systems
Clustered Regularly Interspaced Short Palindromic Repeats*
DNA Damage
Gene Editing*
Tumor Suppressor Protein p53 / genetics

Substances

Tumor Suppressor Protein p53

Grants and funding

R01 CA195787/CA/NCI NIH HHS/United States