Precision medicine in food allergy

Curr Opin Allergy Clin Immunol. 2018 Oct;18(5):438-443. doi: 10.1097/ACI.0000000000000465.

Abstract

Purpose of review: To familiarize the reader with the concept of precision medicine in food allergy through the most recent insights in the diagnosis, prognosis, and management of the disease.

Recent findings: With the advent of omics sciences, a new era is commencing. Food protein allergens characterization and quantification together with the immunoglobulin E epitope mapping will contribute to the diagnosis/prognosis of food allergy and will lead to a better safety assessment of foods. The characterization of biomarkers able to identify specific phenotypes and endotypes will improve the diagnostic accuracy. This together with a better understanding of mechanisms of action of the different therapeutic options will allow the accurate selection of the appropriate patient.

Summary: In the near future, advances in technologies and data interpretation will allow a better understanding of the pathogenesis of food allergy and the development of a personalized treatment tailored on the specific patient' profile.

Publication types

  • Review

MeSH terms

  • Allergens / immunology*
  • Cross Reactions / immunology
  • Desensitization, Immunologic / methods
  • Dietary Proteins / immunology*
  • Epitope Mapping
  • Food Hypersensitivity / diagnosis
  • Food Hypersensitivity / immunology*
  • Food Hypersensitivity / therapy
  • Humans
  • Immunoglobulin E / immunology
  • Phenotype
  • Precision Medicine*
  • Prognosis
  • Proteomics

Substances

  • Allergens
  • Dietary Proteins
  • Immunoglobulin E