Intracarotid amobarbital disrupts synchronous and nested oscillatory activity ipsilateral to injection

James J Young; Joshua S Friedman; Thomas J Oxley; Christina Palmese; Fedor Panov; Saadi Ghatan; Johanna T Fifi; Lara V Marcuse

doi:10.1016/j.ebcr.2018.04.003

Intracarotid amobarbital disrupts synchronous and nested oscillatory activity ipsilateral to injection

Epilepsy Behav Case Rep. 2018 Apr 25:10:25-28. doi: 10.1016/j.ebcr.2018.04.003. eCollection 2018.

Authors

James J Young^{1

2}, Joshua S Friedman¹, Thomas J Oxley², Christina Palmese¹, Fedor Panov², Saadi Ghatan², Johanna T Fifi², Lara V Marcuse¹

Affiliations

¹ Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
² Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Abstract

The mechanism of amobarbital action during the intracarotid amobarbital procedure is poorly understood. We report a patient case who underwent IAP while implanted with bilateral stereo-EEG. We analyzed the spectral power, phase amplitude coupling, and cluster-phase group synchrony during the procedure. Delta and gamma power increased bilaterally. By contrast, phase amplitude coupling increased only ipsilateral to the injection. Similarly, 4-30 Hz cluster-phase group synchrony declines and gamma cluster-phase group synchrony increases only ipsilateral to the injection. These results suggest that a possible additional mechanism for amobarbital action in the IAP is by altering the precise timing of oscillatory activity.

Keywords: Epilepsy surgery; Intracarotid amobarbital procedure; Phase amplitude coupling; Stereo-EEG; Synchrony; Wada.

Publication types

Case Reports