Endothelial-cell inflammation and damage by reactive oxygen species are prevented by propofol via ABCA1-mediated cholesterol efflux

Int J Med Sci. 2018 Jun 14;15(10):978-985. doi: 10.7150/ijms.24659. eCollection 2018.

Abstract

Background: Cholesterol efflux efficiency, reactive oxygen species, and inflammation are closely related to cardiovascular diseases. Our aim was to investigate the effect of propofol on cholesterol-loaded rat aortic endothelial cells after high-density lipoprotein treatment in vitro. Methods and Results: The results showed that propofol promoted cholesterol efflux and ameliorated inflammation and reactive oxygen species overproduction according to the analysis of p65 nuclear translocation and a 2',7'-dichlorofluorescin diacetate assay, respectively. Conclusions: These results provide a possible explanation for the anti-inflammatory, antioxidant, and cholesterol efflux-promoting effects of propofol on rat aortic endothelial cells after incubation with high-density lipoprotein.

Keywords: Propofol; cholesterol efflux; high-density lipoprotein; inflammation; rat aortic endothelial cells; reactive oxygen species.

MeSH terms

  • ATP Binding Cassette Transporter 1 / metabolism
  • ATP Binding Cassette Transporter 1 / physiology*
  • ATP-Binding Cassette Transporters
  • Animals
  • Aorta
  • Cholesterol / metabolism*
  • Endothelial Cells
  • Hypnotics and Sedatives / pharmacology*
  • Inflammation*
  • Propofol / pharmacology*
  • Rats
  • Reactive Oxygen Species*

Substances

  • ABCA1 protein, rat
  • ATP Binding Cassette Transporter 1
  • ATP-Binding Cassette Transporters
  • Hypnotics and Sedatives
  • Reactive Oxygen Species
  • Cholesterol
  • Propofol