CpG Island Methylation in Sessile Serrated Adenomas Increases With Age, Indicating Lower Risk of Malignancy in Young Patients

Cheng Liu; Mark L Bettington; Neal I Walker; Joel Dwine; Gunter F Hartel; Barbara A Leggett; Vicki L J Whitehall

doi:10.1053/j.gastro.2018.07.012

CpG Island Methylation in Sessile Serrated Adenomas Increases With Age, Indicating Lower Risk of Malignancy in Young Patients

Gastroenterology. 2018 Nov;155(5):1362-1365.e2. doi: 10.1053/j.gastro.2018.07.012. Epub 2018 Oct 4.

Authors

Cheng Liu¹, Mark L Bettington², Neal I Walker², Joel Dwine³, Gunter F Hartel⁴, Barbara A Leggett⁵, Vicki L J Whitehall⁶

Affiliations

¹ The Conjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia. Electronic address: john.liu@qimrberghofer.edu.au.
² Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia; Envoi Specialist Pathologists, Brisbane, Queensland, Australia.
³ Envoi Specialist Pathologists, Brisbane, Queensland, Australia.
⁴ Statistics Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
⁵ The Conjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia; The Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
⁶ The Conjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia; Department of Chemical Pathology, Pathology Queensland, Brisbane, Queensland, Australia.

PMID: 30009818
DOI: 10.1053/j.gastro.2018.07.012

Abstract

Among sessile serrated adenomas (SSAs) with identical histologic features, some never progress, whereas others become dysplastic and develop into invasive cancers. Development of the CpG island methylator phenotype is a feature of SSA progression; we examined the CIMP status of 448 SSAs and examined the association with patient clinical data. Overall, 190 SSAs were CpG island methylator phenotype-positive. CpG island methylator phenotype positivity was associated with older patient age (P < .001) and proximal polyp site (P < .001), but not with patient sex (P = .94) or polyp size (P = .34). These results might be used to improve SSA surveillance guidelines.

Keywords: Colonoscopy; Colorectal Cancer; Gene Silencing; Serrated Pathway.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenoma / genetics*
Adult
Age Factors
Aged
Aged, 80 and over
CpG Islands*
DNA Methylation*
Female
Humans
Male
Middle Aged
Neoplasms / etiology*
Neoplasms / genetics