Targeting of drug-loaded nanoparticles to tumor sites increases cell death and release of danger signals

Magdalena Alev; Laura Egenberger; Laura Mühleisen; Bianca Weigel; Benjamin Frey; Ralf P Friedrich; Marina Pöttler; Christoph Alexiou; Christina Janko

doi:10.1016/j.jconrel.2018.07.007

Targeting of drug-loaded nanoparticles to tumor sites increases cell death and release of danger signals

J Control Release. 2018 Sep 10:285:67-80. doi: 10.1016/j.jconrel.2018.07.007. Epub 2018 Jul 4.

Authors

Magdalena Alev¹, Laura Egenberger², Laura Mühleisen³, Bianca Weigel⁴, Benjamin Frey⁵, Ralf P Friedrich⁶, Marina Pöttler⁷, Christoph Alexiou⁸, Christina Janko⁹

Affiliations

¹ Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung Professorship, Universitätsklinikum Erlangen, Germany; Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany. Electronic address: magdalena_alev@hotmail.com.
² Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung Professorship, Universitätsklinikum Erlangen, Germany; Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany. Electronic address: laura.egenberger@uk-erlangen.de.
³ Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung Professorship, Universitätsklinikum Erlangen, Germany; Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany. Electronic address: laura.muehleisen@web.de.
⁴ Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung Professorship, Universitätsklinikum Erlangen, Germany. Electronic address: bianca.weigel@uk-erlangen.de.
⁵ Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Germany. Electronic address: benjamin.frey@uk-erlangen.de.
⁶ Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung Professorship, Universitätsklinikum Erlangen, Germany. Electronic address: ralf.friedrich@uk-erlangen.de.
⁷ Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung Professorship, Universitätsklinikum Erlangen, Germany. Electronic address: marina.poettler@uk-erlangen.de.
⁸ Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung Professorship, Universitätsklinikum Erlangen, Germany. Electronic address: christoph.alexiou@uk-erlangen.de.
⁹ Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung Professorship, Universitätsklinikum Erlangen, Germany. Electronic address: christina.janko@uk-erlangen.de.

PMID: 30008372
DOI: 10.1016/j.jconrel.2018.07.007

No abstract available

Keywords: Immunogenic cell death; Magnetic drug targeting (MDT); Nanomedicine; Superparamagnetic iron oxide nanoparticles (SPIONs); Tumor microenvironment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alarmins / metabolism*
Antineoplastic Agents / administration & dosage*
Antineoplastic Agents / pharmacology
Cell Death / drug effects*
Cell Proliferation / drug effects
Drug Delivery Systems / instrumentation
Equipment Design
HT29 Cells
Humans
Jurkat Cells
Magnetite Nanoparticles / chemistry*
Mitoxantrone / administration & dosage*
Mitoxantrone / pharmacology
Neoplasms / drug therapy
Neoplasms / metabolism

Substances

Alarmins
Antineoplastic Agents
Magnetite Nanoparticles
Mitoxantrone