Nitro-fatty acid formation and metabolism

Nitric Oxide. 2018 Sep 1:79:38-44. doi: 10.1016/j.niox.2018.07.003. Epub 2018 Jul 10.

Abstract

Nitro-fatty acids (NO2-FA) are pleiotropic modulators of redox signaling pathways. Their effects on inflammatory signaling have been studied in great detail in cell, animal and clinical models primarily using exogenously administered nitro-oleic acid. While we know a considerable amount regarding NO2-FA signaling, endogenous formation and metabolism is relatively unexplored. This review will cover what is currently known regarding the proposed mechanisms of NO2-FA formation, dietary modulation of endogenous NO2-FA levels, pathways of NO2-FA metabolism and the detection of NO2-FA and corresponding metabolites.

Keywords: Diet; Metabolism; Nitration; Nitric oxide; Nitro-conjugated linoleic acid; Nitro-fatty acid; Nitrogen dioxide.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Fatty Acids / biosynthesis*
  • Fatty Acids / metabolism*
  • Humans
  • Nitric Oxide / metabolism
  • Nitro Compounds / metabolism*
  • Oxidation-Reduction

Substances

  • Fatty Acids
  • Nitro Compounds
  • Nitric Oxide