Association between mismatch negativity and voxel-based brain volume in schizophrenia

Wei-Lieh Huang; Chao-Yu Liu; Chih-Min Liu; Hon-Man Liu; Chung-Yi Yang; Tzung-Jeng Hwang; Ming H Hsieh; Hai-Gwo Hwu

doi:10.1016/j.clinph.2018.06.018

Association between mismatch negativity and voxel-based brain volume in schizophrenia

Clin Neurophysiol. 2018 Sep;129(9):1899-1906. doi: 10.1016/j.clinph.2018.06.018. Epub 2018 Jul 3.

Authors

Wei-Lieh Huang¹, Chao-Yu Liu², Chih-Min Liu³, Hon-Man Liu⁴, Chung-Yi Yang⁵, Tzung-Jeng Hwang³, Ming H Hsieh⁶, Hai-Gwo Hwu³

Affiliations

¹ Department of Psychiatry, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan; Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan.
² Department of Psychiatry, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan.
³ Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Taiwan University, Taipei, Taiwan.
⁴ Department of Medical Imaging, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan; School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
⁵ Department of Medical Imaging, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan; Department of Medical Imaging, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
⁶ Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: hsiehmh@ntu.edu.tw.

PMID: 30005217
DOI: 10.1016/j.clinph.2018.06.018

Abstract

Objective: This study aimed to investigate the association between mismatch negativity (MMN) and volumes of several brain regions measured using a semi-automated method in patients with schizophrenia and healthy controls.

Methods: MMN in response to duration deviants and magnetic resonance imaging were acquired from 36 schizophrenia patients and 14 healthy controls. FreeSurfer was used for volumetric analysis. MMN amplitudes, brain volumes and their association were compared between schizophrenia and controls. Correlation analysis and multiple linear regression analysis were used to examine the correlated variables of MMN.

Results: MMN amplitude was significantly lower in the schizophrenia group. In schizophrenia, MMN was positively correlated with age and negatively correlated with left hippocampal and right pars opercularis volumes. The association between left hippocampal volume and MMN in schizophrenia remained significant after controlling for potential confounders.

Conclusions: Smaller hippocampal volume may play a role in the abnormal manifestation of MMN in schizophrenia.

Significance: The significant association between MMN and left hippocampal volume may suggest unique neurobiological contribution of hippocampus in auditory processing in schizophrenia.

Keywords: Brain volume; Hippocampus; Mismatch negativity; Schizophrenia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acoustic Stimulation
Adult
Brain / diagnostic imaging
Brain / physiopathology*
Electroencephalography
Evoked Potentials / physiology*
Evoked Potentials, Auditory / physiology
Female
Hippocampus / diagnostic imaging
Hippocampus / physiopathology
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Organ Size / physiology
Schizophrenia / diagnostic imaging
Schizophrenia / physiopathology*
Young Adult