[Effect of dalargin on the content of endorphins, leucine-enkephalin ACTH and corticosterone of the blood of stressed rats]

Biull Eksp Biol Med. 1985 Dec;100(12):715-7.
[Article in Russian]

Abstract

Stress caused by acute cysteamine duodenal ulcer was induced in Wistar male rats. All the endogenous opioides under study were involved in the stress-reaction mechanism. Protective dalargin (synthetic enkephalin analogue) administration revealed a tendency towards normalization of endorphin, L-enkephalin and ACTH blood levels.

Publication types

  • Comparative Study

MeSH terms

  • Acute Disease
  • Adrenocorticotropic Hormone / blood*
  • Animals
  • Ascitic Fluid
  • Corticosterone / blood*
  • Drug Evaluation, Preclinical
  • Endorphins / blood*
  • Enkephalin, Leucine / analogs & derivatives*
  • Enkephalin, Leucine / blood*
  • Enkephalin, Leucine / therapeutic use
  • Enkephalin, Leucine-2-Alanine* / analogs & derivatives*
  • Male
  • Peritonitis / blood
  • Peritonitis / drug therapy
  • Peritonitis / etiology
  • Rats
  • Rats, Inbred Strains
  • Stress, Physiological / blood
  • Stress, Physiological / drug therapy*
  • Stress, Physiological / etiology
  • Time Factors
  • Toxins, Biological / toxicity

Substances

  • Endorphins
  • Toxins, Biological
  • Enkephalin, Leucine
  • Enkephalin, Leucine-2-Alanine
  • Adrenocorticotropic Hormone
  • enkephalin-Leu, Ala(2)-Arg(6)-
  • Corticosterone