Abstract
Stress caused by acute cysteamine duodenal ulcer was induced in Wistar male rats. All the endogenous opioides under study were involved in the stress-reaction mechanism. Protective dalargin (synthetic enkephalin analogue) administration revealed a tendency towards normalization of endorphin, L-enkephalin and ACTH blood levels.
MeSH terms
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Acute Disease
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Adrenocorticotropic Hormone / blood*
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Animals
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Ascitic Fluid
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Corticosterone / blood*
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Drug Evaluation, Preclinical
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Endorphins / blood*
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Enkephalin, Leucine / analogs & derivatives*
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Enkephalin, Leucine / blood*
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Enkephalin, Leucine / therapeutic use
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Enkephalin, Leucine-2-Alanine* / analogs & derivatives*
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Male
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Peritonitis / blood
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Peritonitis / drug therapy
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Peritonitis / etiology
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Rats
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Rats, Inbred Strains
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Stress, Physiological / blood
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Stress, Physiological / drug therapy*
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Stress, Physiological / etiology
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Time Factors
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Toxins, Biological / toxicity
Substances
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Endorphins
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Toxins, Biological
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Enkephalin, Leucine
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Enkephalin, Leucine-2-Alanine
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Adrenocorticotropic Hormone
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enkephalin-Leu, Ala(2)-Arg(6)-
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Corticosterone