Plastic Scintillator-Based Microfluidic Devices for Miniaturized Detection of Positron Emission Tomography Radiopharmaceuticals

Mark D Tarn; Nuray Yavuzkanat Kızılyer; Mohammad M N Esfahani; Pankaj Joshi; Nathaniel J Brown; Nicole Pamme; David G Jenkins; Stephen J Archibald

doi:10.1002/chem.201802395

Plastic Scintillator-Based Microfluidic Devices for Miniaturized Detection of Positron Emission Tomography Radiopharmaceuticals

Chemistry. 2018 Sep 18;24(52):13749-13753. doi: 10.1002/chem.201802395. Epub 2018 Aug 20.

Authors

Mark D Tarn^{1

2

3}, Nuray Yavuzkanat Kızılyer^{4

5}, Mohammad M N Esfahani^{1

6}, Pankaj Joshi⁴, Nathaniel J Brown⁶, Nicole Pamme², David G Jenkins⁴, Stephen J Archibald^{1

2}

Affiliations

¹ Positron Emission Tomography Research Centre, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
² School of Mathematics and Physical Sciences, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
³ Current address: School of Earth and Environment, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK.
⁴ Department of Physics, University of York, Heslington, York, YO10 5DD, UK.
⁵ Current address: Faculty of Art and Science, Bitlis Eren University, Bitlis, 13000, Turkey.
⁶ School of Engineering and Computer Science, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.

PMID: 30003615
DOI: 10.1002/chem.201802395

Abstract

A miniaturized radio-HPLC detector has been developed comprising a microfluidic device fabricated from plastic scintillator in combination with a silicon photomultiplier light sensor, and tested with samples containing a positron-emitting radionuclide, [¹⁸ F]fluoride. This cost-effective, small footprint analytical tool is ideal for incorporation into integrated quality control systems for the testing of positron emission tomography (PET) radiopharmaceuticals to good manufacturing practice (GMP) standards.

Keywords: liquid chromatography; microfluidics; plastic scintillator; positron emission tomography; radiopharmaceuticals; silicon photomultiplier.

Abstract

Grants and funding