Quantitative integration of epigenomic variation and transcription factor binding using MAmotif toolkit identifies an important role of IRF2 as transcription activator at gene promoters

Cell Discov. 2018 Jul 10:4:38. doi: 10.1038/s41421-018-0045-y. eCollection 2018.

Hongduo Sun^#^{1

2}, Jiawei Wang^#³, Zhaohui Gong^#¹, Jiaying Yao^#^{1

2}, Yuangao Wang¹, Jian Xu⁴, Guo-Cheng Yuan^{5

6}, Yijing Zhang³, Zhen Shao¹

¹ 1CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
² 2University of Chinese Academy of Sciences, Beijing 100049, China.
³ 3National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
⁴ 4Children's Medical Center Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA.
⁵ 5Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115 USA.
⁶ 6Harvard Stem Cell Institute, Cambridge, MA 02138 USA.

^# Contributed equally.

No abstract available