Ventral hernia repair in rat using nanofibrous polylactic acid/polypropylene meshes

Nanomedicine (Lond). 2018 Sep;13(17):2187-2199. doi: 10.2217/nnm-2018-0165. Epub 2018 Jul 12.

Abstract

Aim: In the present study, we combined a nanofibrous polylactic acid (PLA) scaffold fabricated by electrospinning with a polypropylene (PP) material to generate a new type of mesh for hernia repair.

Materials & methods: The PLA/PP mesh was tested with tensile testing, in vitro cytocompatibility and degradation. A total of 90 rats were randomly allocated to PLA/PP, PP and polyester (PE) mesh groups for the in vivo study to evaluate the properties of PLA/PP mesh.

Results: PLA/PP mesh had superior mechanical properties. It also resulted in less inflammation adhesion formation (p < 0.05), which was related to the TGF-β1/Smad pathway. The distribution of collagen I and III in PLA/PP mesh was also superior to those in the other two groups (p < 0.05).

Conclusion: The PLA/PP mesh would be suitable for ventral hernia repair in the future.

Keywords: TGF-β; antiadhesion; electrospinning; hernia; polylactic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials
  • Cell Line
  • Collagen Type I / metabolism
  • Collagen Type III / metabolism
  • Hernia, Ventral / therapy*
  • Humans
  • Inflammation / prevention & control
  • Male
  • Nanofibers / chemistry*
  • Nanofibers / therapeutic use
  • Polyesters / chemistry*
  • Polypropylenes / chemistry*
  • Rats, Sprague-Dawley
  • Surgical Mesh*
  • Tissue Adhesions / prevention & control
  • Tissue Engineering

Substances

  • Biocompatible Materials
  • Collagen Type I
  • Collagen Type III
  • Polyesters
  • Polypropylenes
  • poly(lactide)