Power-law relationship in the long-tailed sections of proton dose distributions

Sci Rep. 2018 Jul 10;8(1):10413. doi: 10.1038/s41598-018-28683-5.

Abstract

The halo portion of a proton therapy dose creates a long tail in proton dose distributions, but so far study of this phenomenon has been limited. We used statistical methods and mathematical models to confirm that the long-tailed portion of proton dose distributions exhibits a power-law relationship. By analyzing 299 measured dose profiles, we found that all proton lateral dose distributions had a significant power-law scaling correlation with a high correlation coefficient in the tail. We set up a dual-mechanism model, containing both direct and indirect impact mechanisms. In the direct impact mechanism, the proximal dose deposition is mainly due to the direct impact of a proton on a particle. In the indirect mechanism, the impact of a proton on a given particle is considered in terms of the proton's impact on a neighboring particle that then impacts the given particle. We found that the indirect impact mechanism led to a tail in the distribution exhibiting a power-law relationship because the probability of the indirect impacts was proportional to the distance; i.e., the longer the distance, the larger the indirect impact probability. Upon analyzing the experimental data, we observed that the power-law exponent increased with proton energy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dose-Response Relationship, Drug*
  • Humans
  • Models, Theoretical*
  • Particle Size
  • Proton Therapy*
  • Protons / adverse effects

Substances

  • Protons