Cooperation of intrathymic T15 idiotype-bearing B and complementary T cells in ontogeny of natural Treg cells involved in establishment of T15 clonal dominance

R Metlas; T Srdic-Rajic; H Kohler

doi:10.1016/j.imlet.2018.07.002

Cooperation of intrathymic T15 idiotype-bearing B and complementary T cells in ontogeny of natural Treg cells involved in establishment of T15 clonal dominance

Immunol Lett. 2018 Aug:200:52-54. doi: 10.1016/j.imlet.2018.07.002. Epub 2018 Jul 7.

Authors

R Metlas¹, T Srdic-Rajic², H Kohler³

Affiliations

¹ Institute of Nuclear Sciences VINCA, Belgrade, Serbia. Electronic address: metlas.r@sbb.rs.
² National Cancer Research Center, Department of Experimental Pharmacology, Belgrade, Serbia. Electronic address: tsrdic@gmail.com.
³ University of Kentucky, Department of Microbiology and Immunology, Lexington, KY, USA. Electronic address: heinz.kohler@uky.edu.

PMID: 29990514
DOI: 10.1016/j.imlet.2018.07.002

Abstract

The mechanisms for dominant T15 idiotype selection are not well understood, yet the significance of idiotypic regulation has been suggested. We proposed that to become dominant V regions of a given subset of B-1a cell must establish a functional idiotypic network with complementary T cells. Features required for the cells involved in immune network and steps preceding the establishment of clonal dominance are suggested.

Keywords: B cell clonal dominance; B cell/T cell idiotypic network; Key words; nTregs commitment.

Publication types

Letter

MeSH terms

Animals
B-Lymphocyte Subsets / immunology*
B-Lymphocyte Subsets / metabolism*
Clonal Selection, Antigen-Mediated*
Immunoglobulin Idiotypes / immunology
Mice
Models, Immunological
T-Lymphocyte Subsets / immunology*
T-Lymphocyte Subsets / metabolism*
T-Lymphocytes, Regulatory / immunology
T-Lymphocytes, Regulatory / metabolism
Thymus Gland / immunology*
Thymus Gland / metabolism*

Substances

Immunoglobulin Idiotypes