Tubular carcinomas of the breast: an epidemiologic study

Future Oncol. 2018 Dec;14(29):3037-3047. doi: 10.2217/fon-2018-0385. Epub 2018 Jul 10.

Abstract

Aim: We explored the clinicopathologic characteristics, prognostic factors and outcomes in tubular carcinoma (TC) of the breast.

Methods: We retrospectively assessed 8091 TC patients using the SEER database from 2000 to 2013.

Results: Most patients were non-Hispanic white, well-differentiated disease, tumor size ≤2 cm, node-negative, nonmetastatic, hormone receptor-positive and HER2-negative status. The 10-year breast cancer-specific survival and overall survival were 98.1 and 82.0%, respectively. Multivariate analysis indicated that age, ethnicity, surgery procedures, radiotherapy and chemotherapy were independent predictors affecting survival outcomes. There was comparable breast cancer-specific survival between surgery and nonsurgery groups.

Conclusion: The patients with TC has excellent survival outcomes, which may in part be due to the favorable tumor characteristics.

Keywords: SEER; breast cancer; epidemiologic study; prognosis; treatment; tubular carcinomas.

MeSH terms

  • Adenocarcinoma / mortality*
  • Adenocarcinoma / pathology
  • Adenocarcinoma / therapy
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms / mortality*
  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy
  • Chemoradiotherapy, Adjuvant / methods
  • Chemoradiotherapy, Adjuvant / statistics & numerical data
  • Female
  • Humans
  • Lymphatic Metastasis / pathology
  • Mastectomy / statistics & numerical data*
  • Middle Aged
  • Prognosis
  • Receptor, ErbB-2 / metabolism
  • Receptors, Estrogen / metabolism
  • Receptors, Progesterone / metabolism
  • Retrospective Studies
  • SEER Program / statistics & numerical data*
  • Survival Analysis
  • Treatment Outcome

Substances

  • Receptors, Estrogen
  • Receptors, Progesterone
  • ERBB2 protein, human
  • Receptor, ErbB-2