Is this really just "fatigue"? A case series of immune-related central adrenal insufficiency secondary to immune checkpoint inhibitors

Misako Nagasaka; Nadine Abdallah; Julie Samantray; Ammar Sukari

doi:10.1002/ccr3.1567

Is this really just "fatigue"? A case series of immune-related central adrenal insufficiency secondary to immune checkpoint inhibitors

Clin Case Rep. 2018 May 24;6(7):1278-1281. doi: 10.1002/ccr3.1567. eCollection 2018 Jul.

Authors

Misako Nagasaka^{1

2}, Nadine Abdallah³, Julie Samantray⁴, Ammar Sukari¹

Affiliations

¹ Department of Oncology Barbara Ann Karmanos Cancer Institute Wayne State University School of Medicine Detroit MI USA.
² Department of Advanced Medical Innovation St. Marianna University Graduate School of Medicine Kawasaki Kanagawa Japan.
³ Department of Medicine Wayne State University Detroit MI USA.
⁴ Department of Endocrinology Wayne State University Detroit MI USA.

Abstract

While immunotherapy with programmed cell death protein 1 (PD1) checkpoint inhibition has shown promising activity against many tumor types, adverse events are common. Hypophysitis is a rare but serious immune-related event known to occur with anti-PD1 inhibition. It will become more prevalent as the usage of checkpoint inhibitors increases.

Keywords: PD1/L1 checkpoint inhibitor; fatigue; immune‐related hypophysitis.

Publication types

Case Reports