Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy

Nobuo Kondoh; Masako Mizuno-Kamiya; Eiji Takayama; Harumi Kawati; Naoki Umemura; Yutaka Yamazaki; Kenji Mitsudo; Iwai Tohnai

doi:10.2174/1874210601812010455

Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy

Open Dent J. 2018 Jun 20:12:455-465. doi: 10.2174/1874210601812010455. eCollection 2018.

Authors

Nobuo Kondoh¹, Masako Mizuno-Kamiya², Eiji Takayama¹, Harumi Kawati¹, Naoki Umemura¹, Yutaka Yamazaki³, Kenji Mitsudo⁴, Iwai Tohnai⁴

Affiliations

¹ Department of Oral Biochemistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry, 1851 Hozumi, Mizuho, Gifu, 501-0296, Japan.
² Department of Management and Information Studies, Chemistry Laboratory, Asahi University School of Business Administration, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan.
³ Department of Oral Health Science, Gerodontology, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Kita-13, Nishi-7, Kita-ku, Sapporo, 060-8586, Japan.
⁴ Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.

Abstract

Introduction: In order to survive, cancers control immune systems and evade immune detection using mediators consisting of immune checkpoint molecules and cellular systems associated with immune suppression.

Methodology: During the development of cancer and chronic infections, the immune checkpoints and cellular components including regulatory T cells, myeloid derived suppressor cells and cancer associated fibroblasts are often enhanced as a mechanism of immune subversion and have therefore become very important therapeutic targets.

Conclusion: In this review, we will discuss the complexity of immune-suppressive mechanisms in the tumor milieu of cancers, including oral malignancy.

Keywords: Cancer-Associated Fibroblasts (CAFs); Immune suppression; Myeloid Derived Suppressor Cell (MDSC); Oral malignancy; T-Regulatory cell (Treg); Tumor Microenvironment (TME).

Publication types

Review