Mouse Models of Asthma

Methods Mol Biol. 2018:1809:351-362. doi: 10.1007/978-1-4939-8570-8_23.

Abstract

Mouse models are critical for delineating the mechanisms that underlie asthma pathogenesis and developing new treatments. In this chapter we describe four different asthma models that offer unique benefits and allow investigators to answer distinct research questions. We also describe key surgical procedures that are necessary for assessing experimental asthma.

Keywords: Allergen; Bronchoalveolar lavage; Experimental asthma; Immunization; Lung; Mouse model.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Allergens / immunology
  • Animals
  • Asthma / etiology*
  • Asthma / physiopathology
  • Bronchoalveolar Lavage
  • Disease Models, Animal
  • Immunization
  • Immunoglobulin E / immunology
  • Mice

Substances

  • Allergens
  • Immunoglobulin E