A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units

Chem Commun (Camb). 2018 Jul 19;54(59):8218-8221. doi: 10.1039/c8cc04363a.

Abstract

A highly hydrophilic polymer equipped with guanidinium groups was used to load aromatic ring-containing hydrophobic agent doxorubicin (DOX) via π-π interaction. The results have shown that the delivery system exhibited enhanced cellular uptake and antitumor efficiency compared with free drugs. This study opens new avenues for the application of hydrophilic polymers in drug delivery.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Doxorubicin / chemistry
  • Doxorubicin / pharmacology*
  • Drug Carriers / chemical synthesis
  • Drug Carriers / chemistry*
  • Drug Liberation
  • Female
  • Fluorescence
  • Guanidines / chemistry*
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • MCF-7 Cells
  • Mice, Inbred BALB C
  • Polymers / chemical synthesis
  • Polymers / chemistry*

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Guanidines
  • Polymers
  • Doxorubicin