Porous Inorganic and Hybrid Systems for Drug Delivery: Future Promise in Combatting Drug Resistance and Translation to Botanical Applications

Junling Guo; Bruno D Mattos; Blaise L Tardy; Vanessa M Moody; Gao Xiao; Hirotaka Ejima; Jiwei Cui; Kang Liang; Joseph J Richardson

doi:10.2174/0929867325666180706111909

Porous Inorganic and Hybrid Systems for Drug Delivery: Future Promise in Combatting Drug Resistance and Translation to Botanical Applications

Curr Med Chem. 2019;26(33):6107-6131. doi: 10.2174/0929867325666180706111909.

Authors

Junling Guo^{1

2}, Bruno D Mattos³, Blaise L Tardy³, Vanessa M Moody⁴, Gao Xiao^{2

5}, Hirotaka Ejima⁶, Jiwei Cui¹, Kang Liang^{7

8

9}, Joseph J Richardson^{6

10}

Affiliations

¹ Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, Shandong University, Jinan, Shandong 250100, China.
² Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, 02115, United States.
³ Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, P. O. Box 16300, FI-00076, Finland.
⁴ Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Pennsylvania 19104, United States.
⁵ Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States.
⁶ Department of Materials Engineering, the University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan.
⁷ School of Chemical Engineering, The University of New South Wales, Sydney, New South Wales, Australia.
⁸ Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales, Australia.
⁹ Australian Centre for NanoMedicine, The University of New South Wales, Sydney, New South Wales, Australia.
¹⁰ Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria, Australia.

PMID: 29984645
DOI: 10.2174/0929867325666180706111909

Abstract

Background: Porous micro- and nanoparticles have the capacity to encapsulate a large quantity of therapeutics, making them promising delivery vehicles for a variety of applications. This review aims to highlight the latest development of inorganic and hybrid (inorganic/ organic) particles for drug delivery with an additional emphasis on combatting drug resistant cancer. We go one step further and discuss delivery applications beyond medicinal delivery, as there is generally a translation from medicinal delivery to botanic delivery after a short lag time.

Methods: We undertook a search of relevant peer-reviewed publications. The quality of the relevant papers was appraised using standard tools. The characteristics of the papers are described herein, and the relevant material and therapeutic properties are discussed.

Results: We discuss 4 classes of porous particles in terms of drug delivery and theranostics. We specifically focus on silica, calcium carbonate, metal-phenolic network, and metalorganic framework particles. Other relevant biomedically relevant applications are discussed and we highlight outstanding therapeutic results in the relevant literature.

Conclusion: The findings of this review confirm the importance of studying and utilizing porous particles for therapeutic delivery. Moreover, we show that the properties of porous particles that make them promising for medicinal drug delivery also make them promising candidates for agro-industrial applications.

Keywords: Nanomedicine; botanic delivery; drug delivery; hybrid; inorganic; porous particles..

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / therapeutic use
Drug Carriers / chemistry*
Drug Resistance, Neoplasm*
Humans
Metal-Organic Frameworks / chemistry
Nanoparticles / chemistry
Neoplasms / drug therapy
Porosity
Silicon Dioxide / chemistry

Substances

Antineoplastic Agents
Drug Carriers
Metal-Organic Frameworks
Silicon Dioxide