Do GST polymorphisms influence in the pathogenesis of diabetic nephropathy?

Mol Cell Endocrinol. 2018 Dec 15:478:10-16. doi: 10.1016/j.mce.2018.07.001. Epub 2018 Jul 5.

Abstract

Diabetic patients often develop Diabetic Nephropathy (DN) despite severe long-lasting hyperglycemia, while others develop DN even under intensive insulin therapy. This indicates that factors other than chronic hyperglycemia may also contribute to the susceptibility to the development of DN. The purpose of this case-control study was to investigate the possible role of GSTM1 and GSTT1 deletion polymorphisms, and Single Nucleotide Polymorphism (SNP), GSTP1 313 A > G (Ile105Val), in DN susceptibility. Multiple logistic regression analysis revealed that the occurrence of GST polymorphisms in the Central Brazilian population was not associated with increased risk of DN. However, the presence GSTT1 null genotype suggest an increase trend in systolic blood pressure and opposite inference was observed for the GSTP1 genotype (Ile⁄Val or Val⁄Val). On the order hand, other studies may clarify the relationship of these polymorphisms with DN and help in the prevention of this disease.

Keywords: Diabetic nephropathy; Genetic polymorphism; Glutathione S-Transferase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diabetic Nephropathies / enzymology*
  • Diabetic Nephropathies / genetics*
  • Female
  • Genetic Predisposition to Disease*
  • Glutathione S-Transferase pi / genetics*
  • Glutathione Transferase / genetics*
  • Humans
  • Male
  • Polymorphism, Genetic*
  • Polymorphism, Single Nucleotide / genetics

Substances

  • glutathione S-transferase T1
  • GSTP1 protein, human
  • Glutathione S-Transferase pi
  • Glutathione Transferase
  • glutathione S-transferase M1