Optimization of relative parameters in transfer entropy estimation and application to corticomuscular coupling in humans

Abstract

Background: As a non-modeled information theoretical measure, the transfer entropy (TE) could be applied to quantitatively analyze the linear and nonlinear coupling characteristics between two observations. However, the parameters selection of TE (the parameters used in state space reconstruction and estimating Shannon entropy) has a serious influence on the accuracy of its results.

New method: In this study, the hybrid particle swarm optimization (HPSO) was applied to improve the accuracy of TE by optimizing its parameters. In HPSO, the TE calculation and significant analysis were integrated into the fitness function, and the optimal parameters group within the parameter space could be automatically found through an iteration process.

Results: The TE results computed under the parameters optimized by HPSO (HPSO-TE), was assessed with a numerical non-linear model, the neural mass model and the recorded electroencephalogram (EEG) and electromyogram (EMG) signals. Compared with TE, HPSO-TE could reduce the 'false positive' in non-linear model, and 'spurious coupling', i.e. two nonzero TEs for unidirectionally coupled systems, especially when coupling strength was weak. The robustness against noise and long time-delay was improved. Moreover, the experimental data analysis showed HPSO-TE revealed the dominant direction (EEG → EMG) in corticomuscular coupling, and had higher values than TE which showed the same dominant direction.

Comparison with existing method: The implication of HPSO improved the accuracy of TE in estimating the coupling strength and direction.

Conclusions: The efficiency of TE could be improved by HPSO for estimating coupling relationships, especially for weakly coupled, strong noisy and long time-delay series.

Keywords: Corticomuscular; Coupling; Hybrid particle swarm optimization; Neural mass model; Parameter optimization; Transfer entropy.