Limonoids from the fruits of Swietenia macrophylla with inhibitory activity against H2O2-induced apoptosis in HUVECs

Ya-Qian Ma; Meng-Han Liu; Kun Jiang; Lan Guo; Shi-Jin Qu; Yi-Qun Wan; Chang-Heng Tan

doi:10.1016/j.fitote.2018.07.001

Limonoids from the fruits of Swietenia macrophylla with inhibitory activity against H₂O₂-induced apoptosis in HUVECs

Fitoterapia. 2018 Sep:129:179-184. doi: 10.1016/j.fitote.2018.07.001. Epub 2018 Jul 5.

Authors

Ya-Qian Ma¹, Meng-Han Liu², Kun Jiang³, Lan Guo⁴, Shi-Jin Qu³, Yi-Qun Wan⁵, Chang-Heng Tan⁶

Affiliations

¹ State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
² The Second Clinical Medical College, Nanchang University, Nanchang 330006, China.
³ Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
⁴ Center of Analysis and Testing, Nanchang University, Nanchang 330047, China.
⁵ State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China; Center of Analysis and Testing, Nanchang University, Nanchang 330047, China. Electronic address: wanyiqun@ncu.edu.cn.
⁶ Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: chtan@simm.ac.cn.

PMID: 29981396
DOI: 10.1016/j.fitote.2018.07.001

Abstract

The fruits of Swietenia macrophylla (skyfruits) are commercially used as healthcare products to improve blood circulation. An investigation of active ingredients of skyfruits led to the isolation of four new limonoids, swietemacrolides A-D (1-4), together with ten known limonoids (5-14) and one proto-limonoid (15). Their structures were elucidated on the basis of MS and NMR data analysis. Swietemacrolide C (3) at the concentration of 10 μM showed significant protective effect on H₂O₂-induced apoptosis in human umbilical vascular endothelial cells (HUVECs), while swieteliacate D (5) displayed moderate anti-apoptotic activity.

Keywords: Antioxidant; Apoptosis; Human umbilical vein endothelial cells; Limonoids; Swietenia macrophylla.

MeSH terms

Apoptosis / drug effects*
Fruit / chemistry*
Human Umbilical Vein Endothelial Cells / drug effects*
Humans
Hydrogen Peroxide
Limonins / isolation & purification
Limonins / pharmacology*
Melanesia
Meliaceae / chemistry*
Molecular Structure

Substances

Limonins
Hydrogen Peroxide