Postmitotic Fate Refinement in the Subplate

Mohammed A Mostajo-Radji; Alex A Pollen

doi:10.1016/j.stem.2018.06.017

Postmitotic Fate Refinement in the Subplate

Cell Stem Cell. 2018 Jul 5;23(1):7-9. doi: 10.1016/j.stem.2018.06.017.

Authors

Mohammed A Mostajo-Radji¹, Alex A Pollen²

Affiliations

¹ Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143, USA.
² Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address: alex.pollen@ucsf.edu.

PMID: 29979992
DOI: 10.1016/j.stem.2018.06.017

Abstract

How is the astonishing diversity of cortical neurons specified? In this issue of Cell Stem Cell, Ozair et al. (2018) leverage hPSC neural differentiation to show that projection neurons undergo prolonged sojourns in the subplate before migrating to deep layers, suggesting that pausing in the subplate may enable integration of intrinsic and extrinsic cues during postmitotic fate refinement.

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MeSH terms

Axons*
Interneurons
Neurons*