Diffusion-weighted magnetic resonance imaging-directed biopsy of a metastatic bone tumor: Lung adenocarcinoma with ALK rearrangement

Makoto Hibino; Yuka Otsuka; Kazunari Maeda; Shigeto Horiuchi; Minoru Fukuda; Tetsuri Kondo

doi:10.1016/j.rmcr.2018.05.024

Diffusion-weighted magnetic resonance imaging-directed biopsy of a metastatic bone tumor: Lung adenocarcinoma with ALK rearrangement

Respir Med Case Rep. 2018 May 24:24:170-172. doi: 10.1016/j.rmcr.2018.05.024. eCollection 2018.

Authors

Makoto Hibino¹, Yuka Otsuka², Kazunari Maeda², Shigeto Horiuchi¹, Minoru Fukuda¹, Tetsuri Kondo¹

Affiliations

¹ Department of Respiratory Medicine, Shonan Fujisawa Tokushukai Hospital, Fujisawa, Japan.
² Department of Internal Medicine, Shonan Fujisawa Tokushukai Hospital, Fujisawa, Japan.

Abstract

A previously healthy 44-year-old Japanese man with a 5-month history of lumbago presented to the emergency department with acute respiratory failure caused by pneumonia, and was immediately intubated. Computed tomography revealed a lung mass, pleural effusion, and multiple osteolytic lesions; however, the results of thoracentesis and bronchial brushing were not definitive. We performed a bone tumor biopsy guided by diffusion-weighted magnetic resonance imaging (DW-MRI) with mechanical ventilation, which enabled the diagnosis of ALK rearrangement-positive lung adenocarcinoma. In the era of precision medicine requiring proper biological tissue collection, DW-MRI was critical for identifying the biopsy site safely and with high precision.

Keywords: Anaplastic lymphoma kinase; Biopsy; CT, computed tomography; Computed tomography; DW, diffusion-weighted; Diffusion-weighted magnetic resonance imaging; Lung cancer; MRI, magnetic resonance imaging.

Publication types

Case Reports