Abstract
A novel Al18F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used to demonstrate direct nose-to-brain uptake following intranasal administration, a common yet controversial delivery route for oxytocin-based therapeutics.
MeSH terms
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Administration, Intranasal
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Animals
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Brain / diagnostic imaging
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Brain / metabolism*
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Female
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Fluorine Radioisotopes
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Half-Life
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Heterocyclic Compounds, 1-Ring / administration & dosage
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Heterocyclic Compounds, 1-Ring / chemical synthesis
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Heterocyclic Compounds, 1-Ring / chemistry
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Heterocyclic Compounds, 1-Ring / pharmacokinetics*
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Male
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Olfactory Bulb / diagnostic imaging
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Olfactory Bulb / metabolism
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Peptides, Cyclic / administration & dosage
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Peptides, Cyclic / chemical synthesis
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / pharmacokinetics*
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Positron-Emission Tomography
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Radiopharmaceuticals / administration & dosage
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Radiopharmaceuticals / chemical synthesis
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Radiopharmaceuticals / chemistry
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Radiopharmaceuticals / pharmacokinetics*
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Rats, Wistar
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Receptors, Oxytocin / metabolism*
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Structure-Activity Relationship
Substances
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Fluorine Radioisotopes
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Heterocyclic Compounds, 1-Ring
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Peptides, Cyclic
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Radiopharmaceuticals
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Receptors, Oxytocin