Salivary pH and colonization by oral Candida in children and adolescents submitted to haemodialysis

Marcia Rejane Thomas Canabarro Andrade; José Alexandre da Rocha Curvelo; Daniel Clemente de Moraes; Maristela Portela; Antonio Ferreira-Pereira; Rosangela Maria de Araújo Soares; Laura Guimarães Primo

doi:10.1111/ipd.12403

Salivary pH and colonization by oral Candida in children and adolescents submitted to haemodialysis

Int J Paediatr Dent. 2018 Jul 4. doi: 10.1111/ipd.12403. Online ahead of print.

Authors

Marcia Rejane Thomas Canabarro Andrade¹, José Alexandre da Rocha Curvelo², Daniel Clemente de Moraes², Maristela Portela³, Antonio Ferreira-Pereira², Rosangela Maria de Araújo Soares², Laura Guimarães Primo⁴

Affiliations

¹ Especific Formation Departament of Health Institute of Nova Friburgo, Universidade Federal Fluminense, Nova Friburgo, RJ, Brasil.
² Institute of Microbiology Professor Paulo de Goés, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
³ Department of Clinics and Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal Fluminense, Niteroi, RJ, Brasil.
⁴ Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

PMID: 29974548
DOI: 10.1111/ipd.12403

Abstract

Background: Fungal infections are a serious problem among haemodialysis patients.

Aim: The aims of this study were to estimate the frequency of oral Candida species among children and adolescents undergoing haemodialysis (HD), to identify the isolated species, and to study the relationship between haemodialysis duration, amounts of colony-forming units, and salivary pH.

Design: A matched sample of 52 patients undergoing HD and 52 healthy individuals were selected. The samples were obtained from the dorsum of the tongue, and the colonies were identified through a substrate assimilation test. Stimulated whole saliva was collected from each patient for evaluation of salivary pH.

Results: The frequency of oral Candida species was 34.6% (18/52) and 46.20% (24/52) in the HD and control groups (P = 0.23), respectively. Candida parapsilosis complex was the most frequently isolated fungi species in the HD group (P = 0.03). A HD therapy duration of more than 1 year was statistically correlated with a higher number of colony-forming units (P = 0.03) but was not statistically related to salivary pH.

Conclusions: Candida parapsilosis complex was the most frequently isolated fungal species in the young HD patients, and the duration therapy was associated with higher oral colonization.