Coexistence of virulence genes in methicillin-resistant Staphylococcus aureus clinical isolates

Rev Soc Bras Med Trop. 2018 May-Jun;51(3):361-363. doi: 10.1590/0037-8682-0339-2017.

Abstract

Introduction: The pathogenic versatility of Staphylococcus aureus is attributed to various virulence genes, including enterotoxins and hemolysins.

Methods: Here, the virulence genes in 177 nosocomial MRSA strains in Porto Alegre, Brazil were detected by PCR.

Results: The overall prevalence rates were as follows: sea, 4.5%; pvl, 18.6%; tst, 27.7%; hla, 87.6%; and hld, 90.4%. No strain contained all tested genes. However, there was frequent coexistence of tst with pvl and hla with hld (40.7% and 26.6%, respectively).

Conclusions: Horizontal transfer of virulence genes is very common in S. aureus, as suggested by the frequent coexistence of several virulence genes.

Publication types

  • Observational Study

MeSH terms

  • Cross-Sectional Studies
  • Humans
  • Methicillin-Resistant Staphylococcus aureus / genetics
  • Methicillin-Resistant Staphylococcus aureus / pathogenicity*
  • Polymerase Chain Reaction
  • Virulence / genetics*
  • Virulence Factors / genetics*

Substances

  • Virulence Factors