A new flavonoid derivative and a new 5-hydroxyanthranilic acid derivative from the sea urchin-derived Streptomyces sp. HDa1

Zhi-Kai Guo; Rong Wang; Tian-Mi Liu; Fu-Xiao Chen; Ming-Qiu Yang

doi:10.1080/10286020.2018.1485663

A new flavonoid derivative and a new 5-hydroxyanthranilic acid derivative from the sea urchin-derived Streptomyces sp. HDa1

J Asian Nat Prod Res. 2019 Oct;21(10):992-998. doi: 10.1080/10286020.2018.1485663. Epub 2018 Jul 4.

Authors

Zhi-Kai Guo¹, Rong Wang², Tian-Mi Liu³, Fu-Xiao Chen², Ming-Qiu Yang²

Affiliations

¹ Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.
² Hainan Academy of Ocean and Fisheries Sciences , Haikou 570206 , China.
³ Hainan Testing Center for the Quality and Safety of Aquatic Products , Haikou 570206 , China.

PMID: 29972031
DOI: 10.1080/10286020.2018.1485663

Abstract

One new flavonoid derivative flavoside A (1), one new 5-hydroxyanthranilic acid derivative crassilin (2), along with the known angucyclinone PD116740 (3) and oxachelin (4), was isolated from the EtOAc extract of the fermentation broth of the sea urchin (Anthocidaris crassispina)-derived actinobacterium, Streptomyces sp. HD01. The structures of these compounds were established on the basis of their HR-ESI-MS and NMR spectroscopic data. All of these compounds were assessed for their antibacterial activity.

Keywords: sp; Actinobacterium; marine natural products; sea urchin.

MeSH terms

Animals
Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology
Bacteria / drug effects
Flavonoids / isolation & purification*
Flavonoids / pharmacology*
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Sea Urchins / microbiology*
Spectrometry, Mass, Electrospray Ionization
Streptomyces / chemistry*

Substances

Anti-Bacterial Agents
Flavonoids