Depolymerized konjac glucomannan: preparation and application in health care

J Zhejiang Univ Sci B. 2018 Jul;19(7):505-514. doi: 10.1631/jzus.B1700310.

Abstract

Konjac glucomannan (KGM) is a water-soluble polysaccharide obtained from the roots and tubers of konjac plants. Recently, a degraded product of KGM, depolymerized KGM (DKGM), has attracted attention because of its low viscosity, improved hydrophily, and favorable physiological functions. In this review, we describe the preparation of DKGM and its prebiotic effects. Other health benefits of DKGM, covering antioxidant and immune activity, are also discussed, as well as its safety. DKGM could be a candidate for use as a tool for the treatment of various diseases, including intestinal flora imbalance, and oxidative- and immune-related disorders.

Keywords: Konjac glucomannan; Depolymerized konjac glucomannan; Prebiotics; Immune response; Antioxidant.

Publication types

  • Review

MeSH terms

  • Amorphophallus / chemistry
  • Animals
  • Antioxidants / isolation & purification
  • Antioxidants / therapeutic use
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Immunologic Factors / isolation & purification
  • Immunologic Factors / therapeutic use
  • Mannans / isolation & purification*
  • Mannans / therapeutic use*
  • Plants, Medicinal / chemistry
  • Polymerization
  • Prebiotics*
  • Safety
  • Viscosity

Substances

  • Antioxidants
  • Immunologic Factors
  • Mannans
  • Prebiotics
  • (1-6)-alpha-glucomannan