Long noncoding RNAs in cervical cancer

J Cancer Res Ther. 2018;14(4):745-753. doi: 10.4103/jcrt.JCRT_669_17.

Abstract

This is a review about long noncoding RNAs (lncRNAs) and cervical cancer, especially the crucial regulating role played by lncRNAs on cervical cancer. LncRNAs are a big family with popular investigation in the last years. LncRNAs, as its noncoding proteins, once were considered to be useless RNAs without much more concern. However, much more attention was paid with the unique relationships between lncRNAs and disease. Especially, lncRNAs were evaluated and found its modifying and regulating functions in the process of cancer development. In this review, we summarize the characteristics of certain lncRNAs which are crucial for cervical cancer, find their mechanisms, and provide more possible direction for following evaluations including the point for target treatment.

Keywords: Cervical cancer; long noncoding RNAs; noncoding RNAs; review.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor
  • Female
  • Gene Expression Regulation, Neoplastic
  • Genetic Predisposition to Disease
  • Humans
  • Neoplasm Metastasis
  • Neoplasm Staging
  • RNA, Long Noncoding / genetics*
  • Uterine Cervical Neoplasms / genetics*
  • Uterine Cervical Neoplasms / metabolism
  • Uterine Cervical Neoplasms / pathology

Substances

  • Biomarkers, Tumor
  • RNA, Long Noncoding