Synchronous MALT lymphoma of the colon and stomach and regression after eradication of Strongyloides stercoralis and Helicobacter pylori

BMJ Case Rep. 2018 Jul 3:2018:bcr2018224795. doi: 10.1136/bcr-2018-224795.

Abstract

Mucosa-associated lymphoid tissue (MALT) is vital for host immunological surveillance against pathogens. MALT lymphoma, also known as extranodal marginal zone B cell lymphoma, is a non-Hodgkin's lymphoma subtype that predominantly arises in the gastrointestinal tract. Chronic Helicobacter pylori (H. pylori) infection is a common cause of gastric MALT lymphoma, although other infections are reported in association with extragastric MALT lymphomas. To our knowledge, here we report the first case of synchronous MALT lymphomas of the colon and stomach in the presence of Strongyloides stercoralis and H. pylori infections that resolved after eradication of both organisms.

Keywords: gastroenterology; stomach and duodenum.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Anti-Bacterial Agents / therapeutic use
  • Antiparasitic Agents / therapeutic use
  • Biomarkers, Tumor
  • Colonic Neoplasms / diagnostic imaging
  • Colonic Neoplasms / pathology*
  • Colonoscopy
  • Gastric Mucosa / diagnostic imaging
  • Gastric Mucosa / pathology
  • Helicobacter Infections / drug therapy*
  • Helicobacter pylori* / drug effects
  • Helicobacter pylori* / isolation & purification
  • Humans
  • Ivermectin / therapeutic use
  • Lymphoma, B-Cell, Marginal Zone / pathology*
  • Male
  • Middle Aged
  • Neoplasms, Multiple Primary / pathology*
  • Stomach Neoplasms / diagnostic imaging
  • Stomach Neoplasms / pathology*
  • Strongyloides stercoralis / drug effects
  • Strongyloides stercoralis / isolation & purification
  • Strongyloidiasis / drug therapy*

Substances

  • Anti-Bacterial Agents
  • Antiparasitic Agents
  • Biomarkers, Tumor
  • Ivermectin