RETRACTED: Downregulation of lncRNA GAS5 confers tamoxifen resistance by activating miR-222 in breast cancer

Juan Gu; Yueping Wang; Xuedong Wang; Daoping Zhou; Chaopeng Shao; Ming Zhou; Zhimin He

doi:10.1016/j.canlet.2018.06.039

RETRACTED: Downregulation of lncRNA GAS5 confers tamoxifen resistance by activating miR-222 in breast cancer

Cancer Lett. 2018 Oct 10:434:1-10. doi: 10.1016/j.canlet.2018.06.039. Epub 2018 Jun 30.

Authors

Juan Gu¹, Yueping Wang², Xuedong Wang³, Daoping Zhou⁴, Chaopeng Shao⁵, Ming Zhou⁶, Zhimin He⁷

Affiliations

¹ Department of Medical Laboratory Science, The Fifth People's Hospital of Wuxi, The Medical School of Jiangnan University Wuxi, Jiangsu, 214000, PR China; Department of Pathology, The Fifth People's Hospital of Wuxi, Nanjing Medical University, Wuxi, Jiangsu, 214000, PR China.
² Department of Medical Laboratory Science, The Fifth People's Hospital of Wuxi, The Medical School of Jiangnan University Wuxi, Jiangsu, 214000, PR China; Department of Biology, College of Arts & Science, Massachusetts University, Boston, MA, 02125, USA; Department of Oncology, The Second People's Hospital of Anhui Province, Anhui Medical University, Hefei, Anhui, 230041, PR China.
³ Department of Medical Laboratory Science, The Fifth People's Hospital of Wuxi, The Medical School of Jiangnan University Wuxi, Jiangsu, 214000, PR China; Department of Pathology, The Fifth People's Hospital of Wuxi, Nanjing Medical University, Wuxi, Jiangsu, 214000, PR China; Department of Oncology, The Second People's Hospital of Anhui Province, Anhui Medical University, Hefei, Anhui, 230041, PR China. Electronic address: wxd729@126.com.
⁴ Department of Oncology, The Second People's Hospital of Anhui Province, Anhui Medical University, Hefei, Anhui, 230041, PR China.
⁵ Department of Blood Transfusion, The Second People's Hospital of Shenzhen, Shenzhen, 518035, Guangdong, PR China.
⁶ Cancer Research Institute, Central South University, Changsha, Hunan, 410078, PR China.
⁷ Cancer Hospital and Cancer Research Institute, Guangzhou Medical University, Guangzhou, Guangdong, 510095, PR China.

PMID: 29969658
DOI: 10.1016/j.canlet.2018.06.039

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. Upon investigation, it was discovered that 5 figures contain fabrication. Figures 1C, 3D, 5C, 5D, and 6G contain manipulated and/or duplicated data. The authors requested a corrigendum be published, however, due to the large number of corrections applied (figures 3, 6, 7, 8 and S3), it cannot be concluded that these changes would not alter the conclusions of the paper. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process.

Keywords: Breast cancer; Drug resistance; LncRNA GAS5; MiR-222; Tamoxifen.

Publication types

Research Support, Non-U.S. Gov't
Retracted Publication

MeSH terms

Animals
Antineoplastic Agents, Hormonal / pharmacology
Breast Neoplasms / drug therapy*
Breast Neoplasms / genetics
Breast Neoplasms / pathology
Cell Survival / drug effects
Cell Survival / genetics
Down-Regulation
Drug Resistance, Neoplasm / drug effects*
Drug Resistance, Neoplasm / genetics
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Kaplan-Meier Estimate
MCF-7 Cells
Mice, Nude
MicroRNAs / genetics*
RNA, Long Noncoding / genetics*
Tamoxifen / pharmacology*
Xenograft Model Antitumor Assays / methods*

Substances

Antineoplastic Agents, Hormonal
GAS5 long non-coding RNA, human
MIRN222 microRNA, human
MicroRNAs
RNA, Long Noncoding
Tamoxifen