Pharmacodynamic Target Attainment for Cefepime, Meropenem, and Piperacillin-Tazobactam Using a Pharmacokinetic/Pharmacodynamic-Based Dosing Calculator in Critically Ill Patients

Antimicrob Agents Chemother. 2018 Aug 27;62(9):e01008-18. doi: 10.1128/AAC.01008-18. Print 2018 Sep.

Abstract

This was a prospective study to determine if pharmacokinetic/pharmacodynamic (PK/PD)-based antibiotic dosing software aids in achieving concentration targets in critically ill patients receiving cefepime (n = 10), meropenem (n = 20), or piperacillin-tazobactam (n = 19). Antibiotic calculator doses targeting a >90% probability of target attainment (PTA) differed from package insert doses for 22.4% (11/49) of patients. Target attainment was achieved for 98% of patients (48/49). A PK/PD-based antibiotic dosing calculator provides beta-lactam doses with a high PTA in critically ill patients.

Keywords: beta-lactam; critically ill; pharmacodynamic; pharmacokinetic.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Cefepime / pharmacology*
  • Critical Illness
  • Female
  • Humans
  • Male
  • Meropenem / pharmacology*
  • Microbial Sensitivity Tests / methods
  • Middle Aged
  • Piperacillin / pharmacology*
  • Piperacillin, Tazobactam Drug Combination / pharmacology*
  • Prospective Studies
  • Tazobactam / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Piperacillin, Tazobactam Drug Combination
  • Cefepime
  • Meropenem
  • Tazobactam
  • Piperacillin