Characterization of a Novel SXT/R391 Integrative and Conjugative Element Carrying cfr, blaCTX-M-65, fosA3, and aac(6')-Ib-cr in Proteus mirabilis

Antimicrob Agents Chemother. 2018 Aug 27;62(9):e00849-18. doi: 10.1128/AAC.00849-18. Print 2018 Sep.

Abstract

A novel 139,487-bp SXT/R391 integrative and conjugative element, ICEPmiChnBCP11, was characterized in Proteus mirabilis of swine origin in China. ICEPmiChnBCP11 harbors 20 different antimicrobial resistance genes, including the clinically important rRNA methyltransferase gene cfr, the extended-spectrum β-lactamase gene blaCTX-M-65, fosfomycin resistance gene fosA3, and fluoroquinolone resistance gene aac(6')-Ib-cr An ISPpu12-mediated composite transposon containing various resistance genes and 10 copies of IS26 is inserted in hot spot 4. ICEPmiChnBCP11 was successfully transferred to Escherichia coli.

Keywords: CTX-M; SXT/R391; cfr; fosA; integrative and conjugative element; multidrug resistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • China
  • Conjugation, Genetic / genetics*
  • DNA Transposable Elements / genetics*
  • DNA, Bacterial / genetics
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Escherichia coli / genetics
  • Fluoroquinolones / pharmacology
  • Fosfomycin / pharmacology
  • Gene Transfer, Horizontal / genetics*
  • Methyltransferases / genetics
  • Microbial Sensitivity Tests
  • Phosphotransferases (Alcohol Group Acceptor) / genetics
  • Proteus mirabilis / drug effects*
  • Proteus mirabilis / genetics*
  • Proteus mirabilis / isolation & purification
  • Swine
  • beta-Lactamases / genetics

Substances

  • DNA Transposable Elements
  • DNA, Bacterial
  • Fluoroquinolones
  • Fosfomycin
  • Methyltransferases
  • Phosphotransferases (Alcohol Group Acceptor)
  • beta-Lactamases