Phototherapy-induced blistering reaction and eruptive melanocytic nevi in a child with transient neonatal porphyrinemia

Eszter Karg; László Kovács; Ferenc Ignácz; Erika Varga; Mária Hocsi; Péter Szűts; Lajos Kemény; Csaba Bereczki; Judit Oláh

doi:10.1111/pde.13569

Phototherapy-induced blistering reaction and eruptive melanocytic nevi in a child with transient neonatal porphyrinemia

Pediatr Dermatol. 2018 Sep;35(5):e272-e275. doi: 10.1111/pde.13569. Epub 2018 Jul 1.

Authors

Eszter Karg¹, László Kovács², Ferenc Ignácz³, Erika Varga⁴, Mária Hocsi⁵, Péter Szűts⁵, Lajos Kemény⁴, Csaba Bereczki¹, Judit Oláh⁴

Affiliations

¹ Department of Pediatrics, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
² Department of Dermatology, Erzsébet Hospital, Hódmezővásárhely, Hungary.
³ Department of Optics and Quantum Electronics, University of Szeged, Szeged, Hungary.
⁴ Department of Dermatology and Allergology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
⁵ Department of Pediatrics, Erzsébet Hospital, Hódmezővásárhely, Hungary.

PMID: 29962053
DOI: 10.1111/pde.13569

Abstract

Neonatal blue-light phototherapy induced a blistering reaction followed by eruption of melanocytic nevi on the exposed skin surface of a child with transient neonatal porphyrinemia. New nevi are still developing 4 years after the triggering event. The role of phototoxicity-induced epidermal injury, that of porphyrins and the influence of neonatal blue-light therapy, in this unique phenomenon are discussed.

Keywords: blue-light phototherapy; eruptive melanocytic nevi; transient porphyrinemia.

Publication types

Case Reports

MeSH terms

Blister / etiology
Dermatitis, Phototoxic / etiology*
Humans
Infant
Infant, Newborn
Male
Nevus, Pigmented / etiology*
Nevus, Pigmented / pathology
Phototherapy / adverse effects*
Porphyrins / blood*
Skin / pathology
Skin Neoplasms / etiology*
Skin Neoplasms / pathology

Substances

Porphyrins