External use of Ruyanneixiao cream efficiently blocks precancerous mammary lesions by interfering with glycolysis induced by inhibition of hypoxia inducible factor-1α, hexokinase 2, phosphofructokinase, and pyruvate kinase M2 expression

J Tradit Chin Med. 2017 Apr;37(2):236-43. doi: 10.1016/s0254-6272(17)30050-x.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / enzymology*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / metabolism
  • Drugs, Chinese Herbal / administration & dosage*
  • Female
  • Glycolysis / drug effects
  • Hexokinase / genetics*
  • Hexokinase / metabolism
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / genetics*
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
  • Mammary Glands, Human / drug effects*
  • Mammary Glands, Human / enzymology
  • Mammary Glands, Human / pathology
  • Phosphofructokinases / genetics*
  • Phosphofructokinases / metabolism
  • Pyruvate Kinase / genetics*
  • Pyruvate Kinase / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Skin Cream / administration & dosage

Substances

  • Drugs, Chinese Herbal
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Phosphofructokinases
  • Hexokinase
  • Pyruvate Kinase