Abstract
Efavirenz is used for the management of HIV infection during pregnancy in South Africa (SA), but it is contraindicated in patients with history of depression due to possible suicidal ideation. This study compared suicidal ideation 12-months postpartum among women receiving and not receiving efavirenz in rural SA, where high rates of depression have been identified. Antenatal psychological intimate partner violence (IPV; AOR = 1.04), depression (AOR = 1.06) and detection of efavirenz in dried blood spot at 32 weeks predicted suicidal ideation 12-months postnatally (AOR = 2.29), controlling for antenatal stigma and physical IPV. Findings support using alternative agents for the management of HIV during pregnancy.
Keywords:
Efavirenz; Postpartum; Pregnancy; South Africa; Suicidal ideation; WOMEN.
MeSH terms
-
Adult
-
Alkynes
-
Benzoxazines / adverse effects*
-
Benzoxazines / therapeutic use
-
Contraindications, Drug
-
Cross-Sectional Studies
-
Cyclopropanes
-
Depression / epidemiology
-
Depression / psychology
-
Depression, Postpartum / epidemiology*
-
Depression, Postpartum / psychology
-
Female
-
HIV Infections / drug therapy*
-
HIV Infections / psychology
-
Humans
-
Intimate Partner Violence / psychology
-
Intimate Partner Violence / statistics & numerical data
-
Postpartum Period / psychology*
-
Pregnancy
-
Pregnancy Complications, Infectious / drug therapy*
-
Pregnancy Complications, Infectious / psychology
-
Reverse Transcriptase Inhibitors / adverse effects*
-
Reverse Transcriptase Inhibitors / therapeutic use
-
Risk Factors
-
Rural Population / statistics & numerical data
-
Social Stigma
-
South Africa / epidemiology
-
Suicidal Ideation*
-
Surveys and Questionnaires
-
Young Adult
Substances
-
Alkynes
-
Benzoxazines
-
Cyclopropanes
-
Reverse Transcriptase Inhibitors
-
efavirenz