Three bisabolane-type sesquiterpenes from edible mushroom Pleurotus eryngii

Takashi Kikuchi; Kazutaka Kitaura; Ayaka Katsumoto; Jie Zhang; Takeshi Yamada; Reiko Tanaka

doi:10.1016/j.fitote.2018.06.021

Three bisabolane-type sesquiterpenes from edible mushroom Pleurotus eryngii

Fitoterapia. 2018 Sep:129:108-113. doi: 10.1016/j.fitote.2018.06.021. Epub 2018 Jun 26.

Authors

Takashi Kikuchi¹, Kazutaka Kitaura², Ayaka Katsumoto², Jie Zhang³, Takeshi Yamada², Reiko Tanaka²

Affiliations

¹ Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. Electronic address: t.kikuchi@gly.oups.ac.jp.
² Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
³ School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China.

PMID: 29959051
DOI: 10.1016/j.fitote.2018.06.021

Abstract

Three bisabolane-type sesquiterpenes (1-3) were isolated from the fruiting bodies of king trumpet mushrooms (Pleurotus eryngii), together with a known compound (4). All isolated compounds were evaluated for their inhibitory effects on nitric oxide (NO) production. Among these, 2 exhibited a moderate inhibitory effect on NO production with an IC₅₀ of 90.9 μM.

Keywords: Bisabolane-type; Inhibitory activity on nitric oxide production; Pleurotus eryngii; Sesquiterpene.

MeSH terms

Agaricales / chemistry
Animals
Fruiting Bodies, Fungal / chemistry*
Mice
Molecular Structure
Nitric Oxide / metabolism
Pleurotus / chemistry*
RAW 264.7 Cells
Sesquiterpenes / chemistry*
Sesquiterpenes / isolation & purification

Substances

Sesquiterpenes
Nitric Oxide