Possible SAMe-induced mania

BMJ Case Rep. 2018 Jun 27:2018:bcr2018224338. doi: 10.1136/bcr-2018-224338.

Abstract

This paper describes a patient who presented with mania with psychotic features in the context of concomitant use of S-adenosyl-L-methionine (SAMe) and selective serotonin reuptake inhibitor (SSRI). The aim of this case report is to provide medical practitioners with a greater awareness of the possibility of a psychotic episode and/or mania manifesting with concurrent use of SAMe and SSRI.

Keywords: bipolar I disorder; depressive disorder; drugs: psychiatry; psychiatry (drugs and medicines); psychotic disorders (incl schizophrenia).

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bipolar Disorder / chemically induced*
  • Citalopram / adverse effects
  • Depression / drug therapy*
  • Drug Therapy, Combination / adverse effects
  • Female
  • Hallucinations / chemically induced*
  • Humans
  • S-Adenosylmethionine / adverse effects*
  • Selective Serotonin Reuptake Inhibitors / adverse effects*

Substances

  • Serotonin Uptake Inhibitors
  • Citalopram
  • S-Adenosylmethionine