A new medermycin analog from the marine-derived actinomycetes Streptomyces sp. ZS-A45

Yun Huang; Qing Jiang; Yu-Hong Chen; Da-Shan Zhang; Wan-Jing Ding; Zhong-Jun Ma

doi:10.1080/10286020.2018.1478814

A new medermycin analog from the marine-derived actinomycetes Streptomyces sp. ZS-A45

J Asian Nat Prod Res. 2019 Aug;21(8):826-831. doi: 10.1080/10286020.2018.1478814. Epub 2018 Jun 27.

Authors

Yun Huang¹, Qing Jiang¹, Yu-Hong Chen¹, Da-Shan Zhang¹, Wan-Jing Ding¹, Zhong-Jun Ma¹

Affiliation

¹ a Institute of Marine Biology , Ocean College, Zhejiang University , Zhoushan 316021 , China.

PMID: 29947258
DOI: 10.1080/10286020.2018.1478814

Abstract

A new medermycin analog (1) was isolated from the marine-derived actinomycetes Streptomyces sp. ZS-A45. The structure elucidation of compound 1 was determined by the HRESIMS and extensive NMR analysis. And compound 1 exhibited significant cytotoxicity against PC3 cell lines with IC₅₀ values of 0.81 ± 0.42 μm.

Keywords: cytotoxicity; medermycin analog.

MeSH terms

Actinobacteria / metabolism*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Cell Line, Tumor
Circular Dichroism
Humans
Magnetic Resonance Spectroscopy
Marine Biology
Naphthoquinones / isolation & purification

Substances

Anti-Bacterial Agents
Naphthoquinones
medermycin