DPI formulations for high dose applications - Challenges and opportunities

Regina Scherließ; Christian Etschmann

doi:10.1016/j.ijpharm.2018.06.038

DPI formulations for high dose applications - Challenges and opportunities

Int J Pharm. 2018 Sep 5;548(1):49-53. doi: 10.1016/j.ijpharm.2018.06.038. Epub 2018 Jun 27.

Authors

Regina Scherließ¹, Christian Etschmann²

Affiliations

¹ Department of Pharmaceutics and Biopharmaceutics, Kiel University, Grasweg 9a, 24118 Kiel, Germany. Electronic address: rscherliess@pharmazie.uni-kiel.de.
² Department of Pharmaceutics and Biopharmaceutics, Kiel University, Grasweg 9a, 24118 Kiel, Germany.

PMID: 29940300
DOI: 10.1016/j.ijpharm.2018.06.038

Abstract

This opinion piece gives reasons for high dose DPI applications, points out challenges and shows opportunities and possible solutions for high dose DPI. This piece of work shall set the stage for more in-depth reviews of state of the art and research papers addressing the challenges of high dose DPI which shall be included in the special issue of IJP.

Publication types

Review

MeSH terms

Administration, Inhalation
Animals
Dry Powder Inhalers*
Humans
Lung / metabolism