Inspired by nature, scientists have been engaged in developing deformable artificial systems. Here, we propose an innovative method to realize controllable deformations using asymmetric bubble hydrogel microfibers produced by microfluidic cascaded coaxial devices. Asymmetric geometries, coupled with the mismatched shrinkage ratio, contribute to deformations upon dehydration. The dynamic process can be controlled by regulating bubble sizes, distances and packing modes. Various 4D structures have been constructed. Combined with the 3D printing technique, this proof-of-concept study may open new avenues for bio-engineering and beyond.