The Value of Outbred Rodent Models in Cancer Research

Ioulia Chatzistamou; Elena Farmaki; Vimala Kaza; Hippokratis Kiaris

doi:10.1016/j.trecan.2018.05.004

The Value of Outbred Rodent Models in Cancer Research

Trends Cancer. 2018 Jul;4(7):468-471. doi: 10.1016/j.trecan.2018.05.004. Epub 2018 Jun 7.

Authors

Ioulia Chatzistamou¹, Elena Farmaki², Vimala Kaza³, Hippokratis Kiaris⁴

Affiliations

¹ Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, SC, USA.
² Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, SC, USA.
³ Peromyscus Genetic Stock Center, University of South Carolina, SC, USA.
⁴ Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, SC, USA; Peromyscus Genetic Stock Center, University of South Carolina, SC, USA. Electronic address: kiarish@cop.sc.edu.

PMID: 29937045
DOI: 10.1016/j.trecan.2018.05.004

Abstract

Mouse models of breast cancer are valuable research tools, but their usefulness is restricted by a series of features inherent to their physiology, such as low endogenous estrogens and genetics (inbred status). Depending on the specific questions asked, outbred rodents like Peromyscus may provide answers that laboratory mice cannot.

Keywords: hormone-sensitive breast cancer; host diversity; outbred model; xenograft.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Animals, Outbred Strains*
Biomedical Research*
Humans
Mice
Neoplasms*
Peromyscus