Genomics of Peritoneal Malignancies

Enusha Karunasena; Jonathan Sham; Kevin Wyatt McMahon; Nita Ahuja

doi:10.1016/j.soc.2018.02.004

Genomics of Peritoneal Malignancies

Surg Oncol Clin N Am. 2018 Jul;27(3):463-475. doi: 10.1016/j.soc.2018.02.004.

Authors

Enusha Karunasena¹, Jonathan Sham², Kevin Wyatt McMahon², Nita Ahuja³

Affiliations

¹ Department of Oncology, GI Clinical Cancer Research and Cancer Immunology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institute, 600 North Wolfe Street, Baltimore, MD 21287, USA.
² Department of Surgery, Johns Hopkins Medical Institute, 600 North Wolfe Street, Baltimore, MD 21287, USA.
³ Department of Surgery, Johns Hopkins Medical Institute, 600 North Wolfe Street, Baltimore, MD 21287, USA; Cancer Biology, Department of Oncology, Sidney Kimmel Comprehensive Cancer, Johns Hopkins Medical Institute, 600 North Wolfe Street, Baltimore, MD 21287, USA; Department of Surgery, Yale School of Medicine, PO Box 208062, New Haven, CT 06520-8062, USA. Electronic address: nita.ahuja@yale.edu.

PMID: 29935683
DOI: 10.1016/j.soc.2018.02.004

Abstract

The peritoneum protects the intraabdominal organs. This function is exploited by aggressive cancers originating from organs within the abdomen, resulting in peritoneal metastasis. We discuss genomic variants that may lead to peritoneal metastasis from multiple cancers. Peritoneal malignancies are attributed to epithelial-mesenchymal transition. These metastatic lesions harbor similar genetic mutations to the primary tumor yet may manifest clone-specific aberrations that promote propagation. Peritoneal metastasis are increasingly being treated with surgical resection as an adjunct to radiation, chemotherapy, and other biologic therapies. We describe genetic and genomic variances that are predictive markers for metastasis and burgeoning indicators for peritoneal malignancies.

Keywords: Colorectal; Epigenetics; Genomics; Microarray; Mutations; Ovarian; Pancreatic; Sequencing.

Publication types

Review

MeSH terms

Biomarkers, Tumor / genetics*
Genomics / methods*
Humans
Peritoneal Neoplasms / diagnosis
Peritoneal Neoplasms / genetics*
Peritoneal Neoplasms / therapy

Substances

Biomarkers, Tumor