G-quadruplex DNA targeting alters class-switch recombination in B cells and attenuates allergic inflammation

J Allergy Clin Immunol. 2018 Oct;142(4):1352-1355. doi: 10.1016/j.jaci.2018.06.011. Epub 2018 Jun 20.

Affiliations

¹ Limoges University, Limoges, France.
² INEM - UMR7355, CNRS, Orléans, France.
³ Immunology Unit MICSU and Lebanese University, Faculty of Sciences, Beirut, Lebanon.
⁴ Bordeaux University, Pessac, France; Institute of Biophysics of the CAS, Brno, Czech Republic.
⁵ Limoges University, Limoges, France. Electronic address: cogne@unilim.fr.

PMID: 29935221
DOI: 10.1016/j.jaci.2018.06.011

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Acridines / pharmacology
Allergens / immunology
Animals
B-Lymphocytes / drug effects
B-Lymphocytes / immunology*
Cells, Cultured
Female
G-Quadruplexes*
Hypersensitivity / immunology*
Immunoglobulin Class Switching*
Inflammation / immunology
Mice, Inbred BALB C
Ovalbumin / immunology

Substances

3,11-difluoro-6,8,13-trimethyl-8H-quino(4,3,2-kl)acridinium
Acridines
Allergens
Ovalbumin