Flaviviruses are globally distributed pathogens causing millions of human infections every year. Flaviviruses are arthropod-borne viruses and are mainly transmitted by either ticks or mosquitoes. Mosquito-borne flaviviruses and their interactions with the innate immune response have been well-studied and reviewed extensively, thus this review will discuss tick-borne flaviviruses and their interactions with the host innate immune response.
Keywords: innate immunity; interferon; kyasanur forest disease virus; louping ill virus; omsk hemorrhagic fever virus; powassan virus; tick-borne encephalitis virus; tick-borne flavivirus; viperin.