Two-dimensional (2D) conductive metal-organic frameworks (MOFs) have emerged as a unique class of multifunctional materials due to their compositional and structural diversity accessible through bottom-up self-assembly. This feature article summarizes the progress in the development of 2D conductive MOFs with emphasis on synthetic modularity, device integration strategies, and multifunctional properties. Applications spanning sensing, catalysis, electronics, energy conversion, and storage are discussed. The challenges and future outlook in the context of molecular engineering and practical development of 2D conductive MOFs are addressed.